Publications

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(2023)

• Sabogal-Guáqueta AM, Marmolejo-Garza A, Trombetta-Lima M, Oun A, Hunneman J, Chen T, Koistinaho J, Lehtonen S, Kortholt A, Wolters JC, Bakker BM, Eggen BJL, Boddeke E, Dolga A. Species-specific metabolic reprogramming in human and mouse microglia during inflammatory pathway induction. Nat Commun. 2023 Oct 13;14(1):6454. doi: 10.1038/s41467-023-42096-7.

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• Taborda Ribas H, Sogayar MC, Dolga AM, Winnischofer SMB, Trombetta-Lima M. Lipid profile in breast cancer: From signaling pathways to treatment strategies. Biochimie. 2023 Nov 21;219:118-129. doi: 10.1016/j.biochi.2023.11.008. 

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• Luo Y, Chatre L, Melhem S, Al-Dahmani ZM, Homer NZM, Miedema A, Deelman LE, Groves MR, Feelisch M, Morton NM, Dolga A, van Goor H. Thiosulfate sulfurtransferase deficiency promotes oxidative distress and aberrant NRF2 function in the brain. Redox Biol. 2023 Dec;68:102965. doi: 10.1016/j.redox.2023.102965

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• Marmolejo-Garza A, Krabbendam IE, Luu MDA, Brouwer F, Trombetta-Lima M, Unal O, O'Connor SJ, Majerníková N, Elzinga CRS, Mammucari C, Schmidt M, Madesh M, Boddeke E, Dolga AM. Negative modulation of mitochondrial calcium uniporter complex protects neurons against ferroptosis. Cell Death Dis. 2023 Nov 25;14(11):772. doi: 10.1038/s41419-023-06290-1.

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• Zhang T, Dolga AM, Eisel ULM, Schmidt M. Novel crosstalk mechanisms between GluA3 and Epac2 in synaptic plasticity and memory in Alzheimer's disease. Neurobiol Dis. 2023;191:106389. doi: 10.1016/j.nbd.2023.106389. 

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• Rizzi J, Moro TR, Winnischofer SMB, Colusse GA, Tamiello CS, Trombetta-Lima M, Noleto GR, Dolga AM, Duarte MER, Noseda MD. Chemical structure and biological activity of the (1 → 3)-linked β-D-glucan isolated from marine diatom Conticribra weissflogii. Int J Biol Macromol. 2023 Jan 1;224:584-593.

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• Oun A, Soliman A, Trombetta-Lima M, Tzepapadaki A, Tsagkari D, Kortholt A, Dolga AM. LRRK2 protects immune cells against erastin-induced ferroptosis. Neurobiol Dis. 2022 Dec;175:105917. 

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• Goldsteen PA, Sabogal Guaqueta AM, Mulder PPMFA, Bos IST, Eggens M, Van der Koog L, Soeiro JT, Halayko AJ, Mathwig K, Kistemaker LEM, Verpoorte EMJ, Dolga AM, Gosens R. Differentiation and on axon-guidance chip culture of human pluripotent stem cell-derived peripheral cholinergic neurons for airway neurobiology studies. Front Pharmacol. 2022 Oct 28;13:991072.

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• Locatelli G, Marques-Ferreira F, Katsoulas A, Kalaitzaki V, Krueger M, Ingold-Heppner B, Walthert S, Sankowski R, Prazeres da Costa O, Dolga A, Huber M, Gold M, Culmsee C, Waisman A, Bechmann I, Milchevskaya V, Prinz M, Tresch A, Becher B, Buch T. IGF1R expression by adult oligodendrocytes is not required in the steady-state but supports neuroinflammation. Glia. 2023 Mar;71(3):616-632.

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• de Ávila Narciso Gomes R, Marmolejo-Garza A, Haan FJ, García TM, Chen T, Mauthe M, Moreira Franco Parisotto YE, Murakami MM Jr, Marie SKN, Baptista MS, Dolga AM, Trombetta-Lima M. Mitochondrial dysfunction mediates neuronal cell response to DMMB photodynamic therapy. Biochim Biophys Acta Mol Cell Res. 2023 Jan 3;1870(3):119429.

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• Oun A, Hoeksema E, Soliman A, Brouwer F, García-Reyes F, Pots H, Trombetta-Lima M, Kortholt A, Dolga AM. Characterization of Lipopolysaccharide Effects on LRRK2 Signaling in RAW Macrophages. Int J Mol Sci. 2023 Jan 13;24(2):1644

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• Han W, Meißner EM, Neunteibl S, Günther M, Kahnt J, Dolga A, Xie C, Plesnila N, Zhu C, Blomgren K, Culmsee C. Dying transplanted neural stem cells mediate survival bystander effects in the injured brain. Cell Death Dis. 2023 Mar 1;14(3):173

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• Corci B, Hooiveld O, Dolga AM, Åberg C. Extending the analogy between intracellular motion in mammalian cells and glassy dynamics. Soft Matter. 2023 Apr 5;19(14):2529-2538. 

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• Vasse GF, Russo S, Barcaru A, Oun AAA, Dolga AM, van Rijn P, Kwiatkowski M, Govorukhina N, Bischoff R, Melgert BN. Collagen type I alters the proteomic signature of macrophages in a collagen morphology-dependent manner. Sci Rep. 2023 Apr 6;13(1):5670. 

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• Ortí-Casañ N, Boerema AS, Köpke K, Ebskamp A, Keijser J, Zhang Y, Chen T, Dolga AM, Broersen K, Fischer R, Pfizenmaier K, Kontermann RE, Eisel ULM. The TNFR1 antagonist Atrosimab reduces neuronal loss, glial activation and memory deficits in an acute mouse model of neurodegeneration. Sci Rep. 2023 Jun 30;13(1):10622.

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• Zhang T, Luu MDA, Dolga AM, Eisel ULM, Schmidt M. The old second messenger cAMP teams up with novel cell death mechanisms: potential translational therapeutical benefit for Alzheimer's disease and Parkinson's disease. Front Physiol. 2023 Jun 19;14:1207280.

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• Chen T, Majerníková N, Marmolejo-Garza A, Trombetta-Lima M, Sabogal-Guáqueta AM, Zhang Y, Ten Kate R, Zuidema M, Mulder PPMFA, den Dunnen W, Gosens R, Verpoorte E, Culmsee C, Eisel ULM, Dolga AM. Mitochondrial transplantation rescues neuronal cells from ferroptosis. Free Radic Biol Med. 2023 Aug 1;208:62-72.

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• Zhang T, Musheshe N, van der Veen CHJTM, Kessels HW, Dolga A, De Deyn P, Eisel U, Schmidt M. The Expression of Epac2 and GluA3 in an Alzheimer's Disease Experimental Model and Postmortem Patient Samples. Biomedicines. 2023 Jul 25;11(8):2096

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• Manzano-Covarrubias AL, Yan H, Luu MDA, Gadjdjoe PS, Dolga AM, Schmidt M. Unravelling the signaling power of pollutants. Trends Pharmacol Sci. 2023 Sep 30:S0165-6147(23)00204-3. doi: 10.1016/j.tips.2023.09.002.

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• Al-Dahmani ZM, Hadian M, Ruiz-Moreno AJ, Maria SA, Batista FA, Zhang R, Luo Y, Sadremomtaz A, van der Straat R, Spoor M, Dolga AM, Dekker FJ, SSA Domling, van Goor H, Groves MR. Identification and Characterization of a Small Molecule that Activates Thiosulfate Sulfurtransferase and Stimulates Mitochondrial Respiration. Protein Sci. 2023 Oct 6:e4794. doi: 10.1002/pro.4794.

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(2022)

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• Oun A, Sabogal-Guaqueta AM, Galuh S, Alexander A, Kortholt A, Dolga AM. The multifaceted role of LRRK2 in Parkinson's disease: From human iPSC to organoids. Neurobiol Dis. 2022 Oct 15;173:105837.

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• Al-Dahmani ZM, Li X, Wiggenhauser LM, Ott H, Kruithof PD, Lunev S, A Batista F, Luo Y, Dolga AM, Morton NM, Groves MR, Kroll J, van Goor H. Thiosulfate sulfurtransferase prevents hyperglycemic damage to the zebrafish pronephros in an experimental model for diabetes. Sci Rep. 2022 Jul 15;12(1):12077.

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• Marmolejo-Garza A, Medeiros-Furquim T, Rao R, Eggen BJL, Boddeke E, Dolga AM. Transcriptomic and epigenomic landscapes of Alzheimer's disease evidence mitochondrial-related pathways. Biochim Biophys Acta Mol Cell Res. 2022 Oct;1869(10):119326. 

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• Khoonkari M, Liang D, Lima MT, van der Land T, Liang Y, Sun J, Dolga A, Kamperman M, van Rijn P, Kruyt FAE. The Unfolded Protein Response Sensor PERK Mediates Stiffness-Dependent Adaptation in Glioblastoma Cells. Int J Mol Sci. 2022 Jun 10;23(12):6520. 

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• Majerníková N, den Dunnen WFA, Dolga AM. Corrigendum: The Potential of Ferroptosis-Targeting Therapies for Alzheimer's Disease: From Mechanism to Transcriptomic Analysis. Front Aging Neurosci. 2022 Mar 8;14:863205. 

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• Ramzan R, Dolga AM, Michels S, Weber P, Culmsee C, Rastan AJ, Vogt S. Cytochrome c Oxidase Inhibition by ATP Decreases Mitochondrial ROS Production. Cells. 2022 Mar 14;11(6):992.

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• Matschke LA, Komadowski MA, Stöhr A, Lee B, Henrich MT, Griesbach M, Rinné S, Geibl FF, Chiu WH, Koprich JB, Brotchie JM, Kiper AK, Dolga AM, Oertel WH, Decher N. Enhanced firing of locus coeruleus neurons and SK channel dysfunction are conserved in distinct models of prodromal Parkinson's disease. Sci Rep. 2022 Feb 24;12(1):3180.

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• Musheshe N, Oun A, Sabogal-Guáqueta AM, Trombetta-Lima M, Mitchel SC, Adzemovic A, Speek O, Morra F, van der Veen CHJT, Lezoualc'h F, Cheng X, Schmidt M, Dolga AM. Pharmacological Inhibition of Epac1 Averts Ferroptosis Cell Death by Preserving Mitochondrial Integrity. Antioxidants (Basel). 2022 Feb 4;11(2):314.

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• Bredehöft J, Dolga AM, Honrath B, Wache S, Mazurek S, Culmsee C, Schoemaker RG, Gerstberger R, Roth J, Rummel C. SK-Channel Activation Alters Peripheral Metabolic Pathways in Mice, but Not Lipopolysaccharide-Induced Fever or Inflammation.  J Inflamm Res. 2022 Jan 23;15:509-531. 

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(2021)

• Majerníková N, den Dunnen WFA, Dolga AM. The Potential of Ferroptosis-Targeting Therapies for Alzheimer's Disease: From Mechanism to Transcriptomic Analysis.  Front Aging Neurosci. 2021 Dec 20;13:745046.

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• Rosenbusch KE, Oun A, Sanislav O, Lay ST, Keizer-Gunnink I, Annesley SJ, Fisher PR, Dolga AM, Kortholt A. A Conserved Role for LRRK2 and Roco Proteins in the Regulation of Mitochondrial Activity. Front Cell Dev Biol. 2021 Sep 8;9:734554. 

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• Goldsteen PA, Yoseif C, Dolga AM, Gosens R. Human pluripotent stem cells for the modelling and treatment of respiratory diseases. Eur Respir Rev. 2021 Aug 3;30(161):210042.

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• Russo L, Mascanzoni F, Farina B, Dolga AM, Monti A, Caporale A, Culmsee C, Fattorusso R, Ruvo M, Doti N. Design, Optimization, and Structural Characterization of an Apoptosis-Inducing Factor Peptide Targeting Human Cyclophilin A to Inhibit Apoptosis Inducing Factor-Mediated Cell Death. J Med Chem. 2021 Aug 12;64(15):11445-11459.

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• Chis AR, Moatar AI, Dijmarescu C, Rosca C, Vorovenci RJ, Krabbendam I, Dolga A, Bejinar C, Marian C, Sirbu IO, Simu M. Plasma hsa-mir-19b is a potential LevoDopa therapy marker. J Cell Mol Med. 2021 Sep;25(18):8715-8724.

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• Marmolejo-Garza A, Dolga AM. PEG out through the pores with the help of ESCRTIII. Cell Calcium. 2021 May 28;97:102422.

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• Trombetta-Lima M, Sabogal-Guáqueta AM, Dolga AM. Mitochondrial dysfunction in neurodegenerative diseases: A focus on iPSC-derived neuronal models.Cell Calcium. 2021 Mar;94:102362.

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• Konstantinidou M, Oun A, Pathak P, Zhang B, Wang Z, Ter Brake F, Dolga AM, Kortholt A, Dömling A. The tale of proteolysis targeting chimeras (PROTACs) for Leucine-Rich Repeat Kinase 2 (LRRK2). ChemMedChem. 2021 Mar 18;16(6):959-965.

 

(2020)

• Goldsteen PA, Dolga AM, Gosens R. Advanced Modeling of Peripheral Neuro-Effector Communication and -Plasticity. Physiology (Bethesda). 2020 Sep 1;35(5):348-357.

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• Trombetta-Lima M, Krabbendam IE, Dolga AM. Calcium-activated potassium channels: implications for aging and age-related neurodegeneration.Int J Biochem Cell Biol. 2020 Jun;123:105748.

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• Sabogal-Guáqueta AM, Marmolejo-Garza A, de Pádua VP, Eggen B, Boddeke E, Dolga AM. Microglia alterations in neurodegenerative diseases and their modeling with human induced pluripotent stem cell and other platforms. Prog Neurobiol. 2020 Jul;190:101805.

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• Krabbendam IE, Honrath B, Dilberger B, Iannetti EF, Branicky RS, Meyer T, Evers B, Dekker FJ, Koopman WJH, Beyrath J, Bano D, Schmidt M, Bakker BM, Hekimi S, Culmsee C, Eckert GP, Dolga AM. SK channel-mediated metabolic escape to glycolysis inhibits ferroptosis and supports stress resistance in C. elegans. Cell Death Dis. 2020 Apr 23;11(4):263.

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• Wegrzyn AB, Herzog K, Gerding A, Kwiatkowski M, Wolters JC, Dolga AM, van Lint AEM, Wanders RJA, Waterham HR, Bakker BM. Fibroblast-specific genome-scale modelling predicts an imbalance in amino acid metabolism in Refsum disease. FEBS J. 2020 Dec;287(23):5096-5113. 

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• Kruithof PD, Lunev S, Aguilar Lozano SP, de Assis Batista F, Al-Dahmani ZM, Joles JA, Dolga AM, Groves MR, van Goor H.Unraveling the role of thiosulfate sulfurtransferase in metabolic diseases. Biochim Biophys Acta Mol Basis Dis. 2020 Jun 1;1866(6):165716.

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• Geng Y, Hernández Villanueva A, Oun A, Buist-Homan M, Blokzijl H, Faber KN, Dolga A, Moshage H. Protective effect of metformin against palmitate-induced hepatic cell death. Biochim Biophys Acta Mol Basis Dis. 2020 Mar 1;1866(3):165621.

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• Richter M, Vidovic N, Biber K, Dolga A, Culmsee C, Dodel R, The neuroprotective role of microglial cells against amyloid beta-mediated toxicity in organotypic hippocampal slice cultures. Brain Pathol. 2020 May;30(3):589-602.

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• Krabbendam IE, Honrath B, Bothof L, Silva-Pavez E, Huerta H, Peñaranda Fajardo NM, Dekker F, Schmidt M, Culmsee C, César Cárdenas J, Kruyt F, Dolga AM. SK channel activation potentiates auranofin-induced cell death in glio- and neuroblastoma cells. Biochem Pharmacol. 2020 Jan;171:113714.

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(2019)​

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• Geng Y, Hernández Villanueva A, Oun A, Buist-Homan M, Blokzijl H, Faber KN, Dolga A, Moshage H. Protective effect of metformin against palmitate-induced hepatic cell death. Biochim Biophys Acta Mol Basis Dis. 2019 Nov 29:165621.

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• Ganjam GK, Bolte K, Matschke LA, Neitemeier S, Dolga AM, Höllerhage M, Höglinger GU, Adamczyk A, Decher N, Oertel WH, Culmsee C. Mitochondrial damage by α-synuclein causes cell death in human dopaminergic neurons. Cell Death Dis. 2019 Nov 14;10(11):865.

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• Michels S, Dolga AM, Braun MD, Kisko TM, Sungur AÖ, Witt SH, Rietschel M, Dempfle A, Wöhr M, Schwarting RKW, Culmsee C. Interaction of the Psychiatric Risk Gene Cacna1c With Post-weaning Social Isolation or Environmental Enrichment Does Not Affect Brain Mitochondrial Bioenergetics in Rats. Front Cell Neurosci. 2019 Oct 25;13:483.

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• Deville S, Honrath B, Tran QTD, Fejer G, Lambrichts I, Nelissen I, Dolga AM, Salvati A. Time-resolved characterization of the mechanisms of toxicity induced by silica and amino-modified polystyrene on alveolar-like macrophages. Arch Toxicol. 2019 Nov 1.

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• Sabogal-Guáqueta AM, Hobbie F, Keerthi A, Oun A, Kortholt A, Boddeke E, Dolga A. Linalool attenuates oxidative stress and mitochondrial dysfunction mediated by glutamate and NMDA toxicity. Biomed Pharmacother. 2019 Oct;118:109295.

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• Yeshaw WM, van der Zwaag M, Pinto F, Lahaye LL, Faber AI, Gómez-Sánchez R, Dolga AM, Poland C, Monaco AP, van IJzendoorn SC, Grzeschik NA, Velayos-Baeza A, Sibon OC. Human VPS13A is associated with multiple organelles and influences mitochondrial morphology and lipid droplet motility. Elife. 2019 Feb 11;8. pii: e43561.

(2018)

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• Silbernagel N, Walecki M, Schäfer MK, Kessler M, Zobeiri M, Rinné S, Kiper AK, Komadowski MA, Vowinkel KS, Wemhöner K, Fortmüller L, Schewe M, Dolga AM, Scekic-Zahirovic J, Matschke LA, Culmsee C, Baukrowitz T, Monassier L, Ullrich ND, Dupuis L, Just S, Budde T, Fabritz L, Decher N. The VAMP-associated protein VAPB is required for cardiac and neuronal pacemaker channel function. FASEB J. 2018 Jun 7:fj201800246R. 

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• Honrath B, Krabbendam IE, IJsebaart C, Pegoretti V, Bendridi N, Rieusset J, Schmidt M, Culmsee C, Dolga AM. SK channel activation is neuroprotective in conditions of enhanced ER-mitochondrial coupling. Cell Death Dis. 2018 May 22;9(6):593. 

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•  Bouwkamp CG, Afawi Z, Fattal-Valevski A, Krabbendam IE, Rivetti S, Masalha R, Quadri M, Breedveld GJ, Mandel H, Tailakh MA, Beverloo HB, Stevanin G, Brice A, van IJcken WFJ, Vernooij MW, Dolga AM, de Vrij FMS, Bonifati V, Kushner SA. ACO2 homozygous missense mutation associated with complicated hereditary spastic paraplegia. Neurol Genet. 2018 Mar 21;4(2):e223. 

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• Matschke LA, Rinné S, Snutch TP, Oertel WH, Dolga AM, Decher N. Calcium-activated SK potassium channels are key modulators of the pacemaker frequency in locus coeruleus neurons. Mol Cell Neurosci. 2018 Apr;88:330-341.

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• Honrath B, Culmsee C, Dolga AM. One protein, different cell fate: the differential outcome of depleting GRP75 during oxidative stress in neurons. Cell Death Dis. 2018 Jan 18;9(2):32.

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• Maher P, van Leyen K, Dey PN, Honrath B, Dolga A, Methner A. The role of Ca(2+) in cell death caused by oxidative glutamate toxicity and ferroptosis. Cell Calcium. 2018 Mar;70:47-55. 

 

(2017)​​ID: 28807815.

• Honrath B, Krabbendam I, Culmsee C, Dolga A. Small conductance Ca(2+)-activated K(+) channels in the plasma membrane, mitochondria and the ER: Pharmacology and implications in neuronal diseases. Neurochem Int. 2017 May 13. pii: S0197-0186(17)30107-9.bh

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• Krabbendam IE, Honrath B, Culmsee C, Dolga AM. Mitochondrial Ca(2+)-activated K(+) channels and their role in cell life and death pathways. Cell Calcium. 2017 Jul 22. Epub ahead of print

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• Pfeiffer A, Schneider J, Bueno D, Dolga A, Voss TD, Lewerenz J, Wüllner V, Methner A. Bcl-x(L) knockout attenuates mitochondrial respiration and causes oxidative stress that is compensated by pentose phosphate pathway activity. Free Radic Biol Med. 2017 Nov;112:350-359. 

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• Lin HK, Boatz JC, Krabbendam IE, Kodali R, Hou Z, Wetzel R, Dolga AM, Poirier MA, van der Wel PCA. Fibril polymorphism affects immobilized non-amyloid flanking domains of huntingtin exon1 rather than its polyglutamine core. Nat Commun. 2017 May 24;8:15462.

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• Zhou K, Xie C, Wickström M, Dolga AM, Zhang Y, Li T, Xu Y, Culmsee C, Kogner P, Zhu C, Blomgren K. Lithium protects hippocampal progenitors, cognitive performance and hypothalamus-pituitary function after irradiation to the juvenile rat brain. Oncotarget. 2017 Mar 16.​

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• Neitemeier S, Jelinek A, Laino V, Hoffmann L, Eisenbach I, Eying R, Ganjam GK, Dolga AM, Oppermann S, Culmsee C. BID links ferroptosis to mitochondrial cell death pathways. Redox Biol. 2017 Mar 9;12:558-570.​

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• Honrath B, Matschke L, Meyer T, Magerhans L, Perocchi F, Ganjam GK, Zischka H, Krasel C, Gerding A, Bakker BM, Bünemann M, Strack S, Decher N, Culmsee C, Dolga AM. SK2 channels regulate mitochondrial respiration and mitochondrial Ca(2+) uptake. Cell Death Differ. 2017 Mar 10. doi: 10.1038/cdd.2017.2.

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• Haanstra JR, Gerding A, Dolga AM, Sorgdrager FJ, Buist-Homan M, du Toit F, Faber KN, Holzhütter HG, Szöör B, Matthews KR, Snoep JL, Westerhoff HV, Bakker BM. Targeting pathogen metabolism without collateral damage to the host. Sci Rep. 2017 Jan 13;7:40406.

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(2016)

• Eleftheriadis N, Poelman H, Leus NG, Honrath B, Neochoritis CG, Dolga A, Dömling A, Dekker FJ. Design of a novel thiophene inhibitor of 15-lipoxygenase-1 with both anti-inflammatory and neuroprotective properties. Eur J Med Chem. 2016 Oct 21;122:786-801.

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• Neitemeier S, Dolga AM, Honrath B, Karuppagounder SS, Alim I, Ratan RR, Culmsee C. Inhibition of HIF-prolyl-4-hydroxylases prevents mitochondrial impairment and cell death in a model of neuronal oxytosis. Cell Death Dis. 2016 May 5;7:e2214.

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• Richter M, Vidovic N, Honrath B, Mahavadi P, Dodel R, Dolga AM, Culmsee C. Activation of SK2 channels preserves ER Ca²⁺ homeostasis and protects against ER stress-induced cell death. Cell Death Differ. 2016 May;23(5):814-27.

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(2015)

• Murthy SR, Sherrin T, Jansen C, Nijholt I, Robles M, Dolga AM, Andreotti N, Sabatier JM, Knaus HG, Penner R, Todorovic C, Blank T. Small-conductance Ca2+-activated potassium type 2 channels regulate the formation of contextual fear memory. PLoS One. 2015 May 4;10(5):e0127264.

 

• Dong F, Eibach M, Bartsch JW, Dolga AM, Schlomann U, Conrad C, Schieber S, Schilling O, Biniossek ML, Culmsee C, Strik H, Koller G, Carl B, Nimsky C. The metalloprotease-disintegrin ADAM8 contributes to temozolomide chemoresistance and enhanced invasiveness of human glioblastoma cells. Neuro Oncol. 2015 Nov;17(11):1474-85.

 

• Richter M, Nickel C, Apel L, Kaas A, Dodel R, Culmsee C, Dolga AM. SK channel activation modulates mitochondrial respiration and attenuates neuronal HT-22 cell damage induced by H2O2. Neurochem Int. 2015 Feb;81:63-75.

 

(2014)

• A.M. Dolga, A.C.F. de Andrade, L. Meissner, H-G. Knaus, M. Höllerhage, P. Christophersen, H. Zischka, N. Plesnila, G.U.Höglinger, C. Culmsee (2014) Subcellular expression and neuroprotective effects of SK channels in human dopaminergic neurons, Cell Death Dis. 5:e999. 

 

• M. Gold, A.M. Dolga, J. Koepke, D. Mengel, C. Culmsee, R. Dodel, A. Koczulla, JP Bach (2014) α1 -antitrypsin modulates microglial-mediated neuroinflammation and protects microglial cells from amyloid-ß-induced toxicity. J Neuroinflammation. 11(1):165.

 

• S. Oppermann, F.C. Schrader, K. Elsässer, A.M. Dolga, A.L. Kraus, N. Doti, C. Wegscheid-Gerlach, M. Schlitzer, C. Culmsee (2014) Novel N-phenyl-substituted thiazolidinediones protect neural cells against glutamate- and tBid-induced toxicity. J Pharmacol Exp Ther. 350:273-289. 

 

• A.K. Streit, L.A. Matschke, A.M. Dolga, S. Rinné, N. Decher (2014) RNA Editing in the Central Cavity as a Mechanism to Regulate Surface Expression of the Voltage-Gated Potassium Channel Kv1.1. J Biol Chem. 289:26762-71. 

 

• C. Reuther, G.K. Ganjam, A.M. Dolga, C. Culmsee (2014) The serine protease inhibitor TLCK attenuates intrinsic death pathways in neurons upstream of mitochondrial demise. Apoptosis. 19:1545-58. 

 

• M. Hollerhage, J. Goebel, A.C.F. de Andrade, T. Hildebrandt, A.M. Dolga, C. Culmsee, W.H. Oertel, B. Hengerer, G.U. Höglinger (2014) Trifluoperazine rescues human post-mitotic dopaminergic neurons from wild-type alpha-synuclein-induced toxicity by reducing small oligomers in a new cellular model of Parkinson's disease, Neurobiol Aging. 35:1700-1711.

 

• M.K.E. Schäfer, A. Pfeiffer, M. Jaeckel, A. Pouya, A.M. Dolga, A. Methner. (2014) Regulators of mitochondrial Ca2+ homeostasis in cerebral ischemia, Cell Tissue Res. 357:395-405. 

 

• N. Doti, C. Reuther, P.L. Scognamiglio, A.M. Dolga, N. Plesnila, M. Ruvo, C. Culmsee (2014) Inhibition of the AIF/CypA complex protects against neuronal death induced by oxidative stress, Cell Death Dis. 5:e993. 

 

(2013)

•  A.M. Dolga, M.F Netter, F. Perocchi, N. Doti, L. Meissner, S. Tobaben, J. Grohm, H. Zischka, N. Plesnila, N. Decher, C. Culmsee (2013) Mitochondrial small conductance SK2 channels prevent glutamate-induced oxytosis and mitochondrial dysfunction. J Biol Chem. 288:10792-804.

 

(2012)

• A.M. Dolga, T. Letsche, M. Gold, N. Doti, M. Bacher, N. Chiamvimonvat, R. Dodel, C. Culmsee (2012) Activation of SK3/KCa2.3 channels modulate the response of LPS-stimulated microglial cells. Glia. 60:2050-64.

 

• A.M. Dolga, C. Culmsee (2012) Protective roles for potassium SK/KCa2 channels in microglia and neurons. Front Pharmacol, 3:196.

 

• E.M Oexler, A.M. Dolga, C. Culmsee (2012) AIF depletion provides neuroprotection through a preconditioning effect. Apoptosis, 17:1027-1038.

 

• Kuiper E, Nelemans A, Luiten P, Nijholt I, A.M. Dolga, Eisel U. (2012) KCa2 and KCa3 channels in learning and memory processes, and neurodegeneration. Front Pharmacol, 3:107

 

• S. Diemert, A.M. Dolga, S. Tobaben, J. Grohm, S. Pfeifer, E. Öxler, C. Culmsee (2012) Impedance measurement for real-time detection of neuronal cell death J Neurosci Methods 203:69-77. 

 

(2011)

• A.M. Dolga, N Terpolilli, F Kepura, IM Nijholt, H-G Knaus, B D’Orsi, JHM Prehn, ULM Eisel, T Plant, N Plesnila and C Culmsee (2011) KCa2 channels activation prevents [Ca2+]i deregulation and reduces neuronal death following glutamate toxicity and cerebral ischemia. Cell Death Dis. 2, e:147.

 

• A.M. Dolga, Culmsee C, de Lau L, Winter Y, Oertel WH, Luiten PG, Eisel UL. (2011) Statins- increasing or reducing the risk of Parkinson's disease? Exp Neurol. 228: 1-4. 

 

(2010)

• Alves MM, Burzynski G, Delalande JM, Osinga J, van der Goot A, A.M. Dolga, de Graaff E, Brooks AS, Metzger M, Eisel UL, Shepherd I, Eggen BJ, Hofstra RM. (2010) KBP interacts with SCG10, linking Goldberg-Shprintzen syndrome to microtubule dynamics and neuronal differentiation. Hum Mol Genet. 18, 3642-3651.

 

(2009)

• P.J. van der Most, A.M. Dolga, I.M. Nijholt, P.G.M. Luiten, and U.L.M. Eisel (2009) Statins: Mechanisms of neuroprotection. Prog Neurobiol. 88, 64-75.

 

• I. Granic, A.M. Dolga, I.M. Nijholt, G. van Dijk and U.L.M. Eisel (2009) Inflammation and NF-κB in Alzheimer's Disease and Diabetes J Alzheimers Dis. 16, 809-821.

 

• A.M. Dolga, I. Granic, I.M. Nijholt, C. Nyakas, van der Zee, E., P.G.M. Luiten and U.L.M. Eisel (2009) Pretreatment with Lovastatin Prevents N-Methyl-D-Aspartate-Induced Neurodegeneration in the Magnocellular Nucleus Basalis and Behavioral Dysfunction. J. Alzheimers. Dis. 17, 327-336. 

 

(2008)

• A.M. Dolga, I. Granic, T. Blank, H-G. Knaus, J. Spiess, P.G.M. Luiten, U.M. Eisel, I.M. Nijholt (2008) TNF mediates neuroprotection against glutamate-induced excitotoxicity via NF-κB-dependent up-regulation of KCa2.2 channels. J. Neurochem. 107, 1158-1167.

 

• S.R. Murthy, G. Teodorescu, I.M. Nijholt, A.M. Dolga, S. Grissmer, J. Spiess and T. Blank (2008) Identification and characterization of a novel, shorter isoform of the small conductance Ca2+ -activated K+ channel KCa2.2. J. Neurochem. 106, 2312-2321. 

 

• I.M. Nijholt, A.M. Dolga, A. Ostroveanu, P.G.M. Luiten, M. Schmidt and U.L.M. Eisel (2008) Neuronal AKAP150 coordinates PKA and Epac mediated PKB/AKT phosphorylation. Cell Signal. 20, 1715-1724.

 

• A.M. Dolga, I.M. Nijholt, A. Ostroveanu, Q. ten Bosch, P.G.M. Luiten, and U.L.M. Eisel (2008) Lovastatin induces neuroprotection through tumor necrosis factor receptor 2 signaling pathways. J. Alzheimers Dis. 13, 111-122.

 

• Knut Biber, A Pinto-Duarte, MC Wittendorp, A.M. Dolga, CC Fernandes, J Von Frijtag Drabbe Kunzel, JN Keijser, R de Vries, AP Ijzerman, JA Ribeiro, U Eisel, AM Sebastiao and HWGM Boddeke (2008) Interleukin-6 Upregulates Neuronal Adenosine A1 Receptors: Implications for Neuromodulation and Neuroprotection.  Neuropsychopharma-cology. 33, 2237-2250. 

 

 (2007)

• A. Ostroveanu, E.A. Van der Zee, A.M. Dolga, P.G.M. Luiten, U.L.M. Eisel, I.M. Nijholt (2007) A-kinase anchoring protein 150 in the mouse brain is concentrated in areas involved in learning and memory, Brain Res. 1145, 97-107.

 

• M.A. De Souza Silva, A.M. Dolga, I. Pieri, L. Marchetti, U.L.M. Eisel, J.P. Huston, and E. Dere (2006) Cholinergic cells in the nucleus basalis of mice express the N-methyl-D-aspartate-receptor subunit NR2C and its replacement by the NR2B subunit enhances frontal and amygdaloid acetylcholine levels, Genes, Brain and Behav. 5, 552-560.